The 2023 Reaching the Last Mile Forum will galvanize new momentum, innovation, and investment to address climate-health challenges confronting last-mile communities. Held under the patronage of His Highness Sheikh Mohamed bin Zayed Al Nahyan, President of the UAE, and in collaboration with the Bill & Melinda Gates Foundation, the forum will convene global, frontline, and community leaders to promote resilient health systems that leave no one behind. The event will be a platform to assess the effects of climate change on human health, with an emphasis on last-mile efforts to end diseases such as polio, malaria, and neglected tropical diseases. Recognizing that inclusive healthcare systems are vital to mitigating the impact of the climate crisis, the discussion will shed light on the innovations, initiatives, and funding models advancing sustainable and equitable healthcare, where it is needed most.